To cite OmicsPLS in publications, please use:
Bouhaddani e, Said, Uh, Won H, Jongbloed, Geurt, Hayward, Caroline, Klari'c, Lucija, Kielbasa, M. S, Houwing-Duistermaat, Jeanine (2018). “Integrating omics datasets with the OmicsPLS package.” BMC Bioinformatics, 19(1). ISSN 1471-2105, doi: 10.1186/s12859-018-2371-3, https://doi.org/10.1186/s12859-018-2371-3.
Corresponding BibTeX entry:
@Article{, author = {el Bouhaddani and {Said} and {Uh} and Hae Won and {Jongbloed} and {Geurt} and {Hayward} and {Caroline} and {Klari{'{c}}} and {Lucija} and {Kielbasa} and Szymon M. and {Houwing-Duistermaat} and {Jeanine}}, title = {Integrating omics datasets with the OmicsPLS package}, journal = {BMC Bioinformatics}, year = {2018}, volume = {19}, number = {1}, abstract = {With the exponential growth in available biomedical data, there is a need for data integration methods that can extract information about relationships between the data sets. However, these data sets might have very different characteristics. For interpretable results, data-specific variation needs to be quantified. For this task, Two-way Orthogonal Partial Least Squares (O2PLS) has been proposed. To facilitate application and development of the methodology, free and open-source software is required. However, this is not the case with O2PLS. We introduce OmicsPLS, an open-source implementation of the O2PLS method in R. It can handle both low- and high-dimensional datasets efficiently. Generic methods for inspecting and visualizing results are implemented. Both a standard and faster alternative cross-validation methods are available to determine the number of components. A simulation study shows good performance of OmicsPLS compared to alternatives, in terms of accuracy and CPU runtime. We demonstrate OmicsPLS by integrating genetic and glycomic data. We propose the OmicsPLS R package: a free and open-source implementation of O2PLS for statistical data integration. OmicsPLS is available at https://cran.r-project.org/package=OmicsPLS and can be installed in R via install.packages(“OmicsPLS”).}, issn = {1471-2105}, doi = {10.1186/s12859-018-2371-3}, url = {https://doi.org/10.1186/s12859-018-2371-3}, }