SimDissolution: Modeling and Assessing Similarity of Drug Dissolutions Profiles

Implementation of a model-based bootstrap approach for testing whether two formulations are similar. The package provides a function for fitting a pharmacokinetic model to time-concentration data and comparing the results for all five candidate models regarding the Residual Sum of Squares (RSS). The candidate set contains a First order, Hixson-Crowell, Higuchi, Weibull and a logistic model. The assessment of similarity implemented in this package is performed regarding the maximum deviation of the profiles. See Moellenhoff et al. (2018) <doi:10.1002/sim.7689> for details.

Version:	0.1.0
Depends:	dplyr, alabama, mvtnorm, graphics
Published:	2019-09-27
Author:	Kathrin Moellenhoff
Maintainer:	Kathrin Moellenhoff <kathrin.moellenhoff at rub.de>
License:	GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation:	no
CRAN checks:	SimDissolution results

Documentation:

Reference manual:

SimDissolution.pdf

Downloads:

Package source:	SimDissolution_0.1.0.tar.gz
Windows binaries:	r-devel: SimDissolution_0.1.0.zip, r-release: SimDissolution_0.1.0.zip, r-oldrel: SimDissolution_0.1.0.zip
macOS binaries:	r-release (arm64): SimDissolution_0.1.0.tgz, r-oldrel (arm64): SimDissolution_0.1.0.tgz, r-release (x86_64): SimDissolution_0.1.0.tgz, r-oldrel (x86_64): SimDissolution_0.1.0.tgz

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