ldsep 2.1.4
- Use unnamed formula argument in
aggregate()
to account for change in R.
ldsep 2.1.2
DOUBLE_EPS
-> DOUBLE_EPSILON
.
- Modified citation to point to Heredity.
- Adds notes about the necessity of using adaptive priors in
ldfast()
.
ldsep 2.1.0
- Includes a
win
argument in ldfast()
, which implements the moment-based LD correction along a sliding window.
- Fixes a bug where monomorphic SNPs were causing errors when
type = "Dprime"
was selected in ldfast()
. Now we just return NA
’s for LD with monomorphic SNPs.
- Uses the complete reference of Gerard (2021) doi:10.1111/1755-0998.13349.
ldsep 2.0.2
- Removes
ldfast_old()
and ldfast_calc()
, which were not used in any exported functions, because these functions had memory issues, detected by valgrind.
ldsep 2.0.1
- Added
ldfast()
, a new LD estimation approach based on sample moments of marginal posterior genotype moments.
- Unlike
ldest()
, mldest()
, and sldest()
, the new approach implemented in ldfast()
is scalable to genome-wide applications, as these new estimators can be calculated in linear time in the sample size.
- Citation of MLE approach points to MER article.
ldsep 1.1.0
- I have changed the terminology from “gametic LD” to “haplotypic” LD, and so all instances of “gametic” have changed to “haplotypic”. A breaking change is that all options that were
"gam"
are now "hap"
.
- Fixed an issue where the title in
plot.lddf()
was being cut off.
- Added a reference to the preprint where the methodology is developed.
- Updated the vignette to also take a user through uploading a VCF file into R using the
VariantAnnotation
package. We also provided examples on formatting genotype likelihoods from updog
and fitpoly
.
ldsep 1.0.0
- Initial release of package.